| DBS | Development Bank of Singapore |
| DBT | Direct Benefit Transfer |
| DC | Direct Current, Data Compression, Deputy Commissioner, District of Columbia, Detective Comics |
| DCA | Diploma in Computer Applications |
| DCE | Diploma in civil Engineering |
| DCIM | Data centre information management, Digital camera images |
| DELL | Digital Electronic Link Library |
| DEST | Data entry Skill test, data entry speed test |
| DLF | Delhi Land and Finance |
| DNA | Deoxyribonucleic acid |
| DNS | Domain Name System |
| DRCC | District Registration cum Counseling Center |
| DRDO | Defense research and development organization |
| DRM | Digital Rights management, Divisional Railway Manager |
| DRS | Decision Review System |
| DSP | Deputy superintendent of police |
| DTP | Desktop publishing, distributed transaction processing |
